Amaranth (Amaranthus spp.) is a popular crop grown throughout sub-Saharan Africa, where both the grain and leaves are consumed. Amaranth cultivars that offer multiple options to small-scale farmers to produce high foliage yields, high grain yields, or both high foliage and grain yields would be desirable. The objective of this study was to determine the effects of multiple leaf harvests on grain yield and grain nutrient content of diverse amaranth entries (breeding lines and cultivars). Trials were conducted at the World Vegetable Center in Arusha, Tanzania in 2013 and 2014.