The report highlights six megatrends shaping the development of agrifood systems in Africa that warrant greater attention by stakeholders. It examines the role of leadership in harnessing collective effort, shared responsibility, greater stakeholder engagement, as well as rallying political will, to achieve food systems transformation in Africa. Further, it presents the investment gap required to trigger and/or sustain Africa’s agro-food transformation reflecting on the requisite human, institutional and systemic capacities and capabilities that are required to achieve agro-food system transformation at scale. And, it recommends priorities for African national governments, development partners and the private sector.