Food supplements and functional foods play a key role in personalized nutrition plans, claiming to modulate physiological functions based on individual needs. As the field of personalized nutrition evolves, it is crucial to consider the safety implications of these products, particularly given their increasing use in recent decades. Although generally perceived as safe, food supplements and functional foods may pose food safety challenges. Additionally, it is important to consider that regulatory inconsistencies across jurisdictions, including definitions and requirements, contribute to significant diversity in the regulation of these products worldwide.