Soybean remains an important crop for the sustenance of livelihoods of resource-constrained farmers in northern Ghana. However, yield of the crop has continuously remained low due to poor soil fertility and low productivity. A two-phase experiment was carried out during the 2019 cropping season to evaluate the growth and yield response of screened soybean genotypes to nitrogen, phosphorus and rhizobia inoculation. In the first phase, growth and yield of 100 selected genotypes were evaluated under optimum phosphorus fertilization using the lattice design. In the second phase, 3 best performing genotypes (N19, N119, N135), selected in phase one together with a known variety (Jenguma) were accessed for growth and yield under phosphorus, nitrogen and inoculants using a 4 (genotype) x 7 (nutrient regime) split plot design. The nutrient regimes were sole triple super phosphate (TSP), sole inoculant, sole booster nitrogen, TSP + booster nitrogen, TSP + inoculant, TSP + booster nitrogen + inoculant and a control (no fertilizer). Each treatment was replicated three times.