Health has been top of mind for most people around the globe during the last two years, as the Covid-19 pandemic upended daily life and critical systems. Beyond Covid-19, the world is facing a number of health crises exacerbated by poverty, including malnutrition and chronic diseases. In many places, people cannot afford nutritious food for their children or the medicines they need. How can businesses innovate to make health more accessible and inclusive? In this issue, we profile entrepreneurs who are changing the game by providing affordability, choice and healthcare solutions for underserved populations.