When we think of food production, especially in Africa, our minds may imagine remote villages across the continent where small-scale farmers dominate the agricultural value chains. However, we are making a huge mistake! Growing urban populations across Africa means that the responsibility for producing environmentally safe and healthy food rests upon the cities as much as the rural areas. Stakeholders in the food value chain in Africa need to work together to promote sustainable food production in cities and ensure the growth of strong food supply chains. The objectives of this issue are to: 1) raise awareness about the increasing African urban population and the need for sustainable food strategies in cities; 2) highlight the best practices in urban food production from cities around the world and key recommendations for urban food systems in Africa; and 3) highlight innovations and initiatives that are increasing food availability and accessibility in cities across Africa.